Scientific Programme

Libor Grubhoffer, Congress Chair, Chairman of the Czech Society for Biochemistry and Molecular Biology

Ján Turňa, Congress Co-Chair, Chairman of the Slovak Society for Biochemistry and Molecular Biology

Chair: Libor Grubhoffer

Laura Ondrišová (Brno, Czech Republic): Unveiling Nongenetic Mechanisms of Adaptation to Targeted Therapy in Chronic Lymphocytic Leukemia

Chair: Marek Šebela

Hana Cahová (Prague, Czech Republic): Dinucleoside Polyphosphates Serve as RNA Caps in Bacteria and Mammalian Cells

„Evening of Memories: Milestones of Czech and Slovak Biochemistry”

„A Tribute night with Daniel Stach“

Chairs: Hassan Hashimi, Peter Celec

09:00 – 09:15 Sponsor Presentation: KRD – IBIDI: Cells in Focus
09:15 – 09:45 Hassan Hashimi (České Budějovice, Czech Republic): Euglenazoans Bend the Rules of How the MICOS Complex Shapes Mitochondria
09:45 – 10:00 Bibiána Baďurová (Martin, Slovakia): The Potential of Dental Stem Cells in the Hard Tissue Regeneration
10:00 – 10:15 Veronika Huntošová (Košice, Slovakia): Modular Carrier Systems for Targeted Cancer Treatment with Multimodal Coverage in Detection and Photodynamic Therapy
10:15 – 10:30 Jan Trnka (Prague, Czech Republic): Pancreatic Cancer Cells Transfer Ribosomes Through Tunneling Nanotubes and Increase Translation in Acceptor Cells

Chairs: Jan Kopecký, Barbara Ukropcová

09:00 – 09:30 Barbora Ukropcová (Bratislava, Slovakia): Exercise and Metabolic Flexibility: Systemic, Muscle and Molecular Markers
09:30 – 10:00 Petr Zouhar (Prague, Czech Republic): Adaptive Induction of Nonshivering Thermogenesis in Muscle Rather Than Brown Fat Could Counteract Obesity
10:00 – 10:10 Alena Pecinová (Prague, Czech Republic): Sequestration of the Polyunsaturated Fatty Acids Protects against Ferroptosis in OXPHOS Deficiency
10:10 – 10:20 Peter Račay (Martin, Slovakia): Involvement of IRE1α in Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction
10:20 – 10:30 Lukáš Alán (Prague, Czech Republic): Von Willebrand Domain-Containing Protein 8 (VWA8) Deletion Promotes Browning of Subcutaneous Adipose Tissue in Mice

Chairs: Martin Marek, Erik Sedlák

09:00 – 09:30 Dominik Oberthür (Hamburg, Germany): A Snapshot Love Story: What Serial Crystallography Has Done and Will Do for Us
09:30 – 10:00 Jakob R. Winther (Copenhagen, Denmark): Can an Enzyme Have a Disordered Active Site and Still Be Highly Specific
10:00 – 10:15 Erik Sedlák (Košice, Slovakia): Evolution of Haloalkane Dehalogenase by Ribosome Display
10:15 – 10:30 Karolína Sedláčková (Brno, Czech Republic): Revealing the Mechanism of Amphiura filiformis Luciferase Action

Chair: Libor Grubhoffer

Paul Nurse (London, United Kingdom): New Perspectives on CDKs and Cell Cycle Control

Chairs: Jiří Vondrášek, Pavlína Maloy Řezáčová

13:30 – 14:00 Jiří Černý (Prague, Czech Republic): Annotation, Validation, Refinement, and Modeling of Nucleic Acid Structures
14:00 – 14:30 Vladena Bauerová (Prague, Czech Republic): Bioinformatic Identification, Expression, Purification and Structural Characterization of Domains of Human Ryanodine Receptor 2
14:30 – 14:45 Kamila Riedlová (Prague, Czech Republic): The Road to Apo Structures: How MD Simulations Help Expand Apo-Holo Datasets and Understand Cryptic Binding Site Dynamics
14:45 – 15:00 Radka Svobodova (Brno, Czech Republic): Partial Atomic Charges for Proteins

Chairs: Štěpánka Vaňáčová, Hana Cahová

13:30 – 14:00 Petr Svoboda (Prague, Czech Republic): Many Layers of Evolution of RNA Interference in Rodent Oocytes
14:00 – 14:30 Mary Anne O’Connell (Brno, Czech Republic): The Lack of the RNA Editing Enzyme Adar1 Reconfigures Immunity During Plasmodium Infection in Mice
14:30 – 14:45 Gabriel Demo (Brno, Czech Republic): Unmasking IF2’s Moves at the Start of Translation
14:45 – 15:00 Aleš Hnízda (Prague, Czech Republic): Distinct Roles of Histone Methyltransferase EHMT1 and EHMT2 in Kleefstra Syndrome

Chairs: Martin Toul, Mária Tomková

13:30 – 13:40 Sponsor Presentation: BioVendor – How to Analyze Biomolecular Interactions Without Labels: Practical Applications of BLI
13:40 – 14:05 Zbyněk Prokop (Brno, Czech Republic): Discovery and Engineering of Biocatalysts Powered by Microfluidics
14:05 – 14:30 Kim Remans (Heidelberg, Germany): Experimental Validation of AlphaDesign, A de novo Protein Design Framework Based on AlphaFold
14:30 – 14:45 Pavel Dvořák (Brno, Czech Republic): Synthetically Primed Adaptation of Bacterial Metabolism to Non-Native Renewable Substrates
14:45 – 15:00 Vladimír Beneš (Heidelberg, Germany): Widening Biotechnology Horizons through Long-read Sequencing

Chair: Vlastimil Kulda

Christina E. Weinberg (Halle, Germany): Unraveling Biology by Studying Ribozymes and Riboswitches

Chair: Vlastimil Kulda

17:00 – 17:20 Vlastimil Kulda (Plzeň, Czech Republic): FEBS and Its Support for Young Scientists
17:20 – 17:40 Pavla Hubálková (Prague, Czech Republic): How and Why to Communicate Science
17:40 – 18:00 Kateřina Rohlenová (Prague, Czech Republic): Navigating the Unknown: A Journey to Becoming a Group Leader

Chairs: Pavel Martásek, Martina Živná

09:00 – 09:20 Stanislav Kmoch (Prague, Czech Republic): The Legacy of Rare Disease Research: Insights for Today and Tomorrow
09:20 – 09:45 Martina Živná (Prague, Czech Republic): Alpha-Galactosidase A Misprocessing-Induced Unfolded Protein Response: Lysosomal Storage-Independent Mechanism of Fabry Disease Pathogenesis
09:45 – 10:00 Peter Celec (Bratislava, Slovakia): Is ‘Cell-Free’ DNA Truly Cell-Free? Implications for Biology and Diagnostics
10:00 – 10:15 Martin Pešta (Plzeň, Czech Republic): Assessment Strategies for Predictive Biomarkers in Targeted Therapy and Immunotherapy of Solid Tumors
10:15 – 10:30 Michal Dvořák (Prague, Czech Republic): Adjuvant Therapy: An Old-New Tool for Tackling Antibiotic Resistance

Chairs: Petr Novák, Jana Havlíková

09:00 – 09:15 Sponsor Presentation: Altium: Binding Matters: Exploring Protein Interactions with Nicoya SPR
09:15 – 09:45 Petr Man (Prague, Czech Republic): Beyond Proline: Discovery of Post-Cysteine Cleavage by Post-Proline Cleaving Enzymes and Its Application in Proteomics
09:45 – 10:00 Alan Kádek (Prague, Czech Republic): Structural Mass Spectrometry and Biophysics Probe Human Papillomavirus and Its Conformational Dynamics During Infection
10:00 – 10:30 Veronika Vidová (Brno, Czech Republic): Multiplexed Proteomics Assay for Quantification of Clinically Relevant Proteins, Their Isoforms and Significant SNPs

Chairs: Michaela Wimmerová, Katarína Mikušová

09:00 – 09:30 Alexei Demchenko (Saint Louis, USA): New Methods and Technologies for the Synthesis of Carbohydrates
09:30 – 10:00 Pavla Bojarová (Prague, Czech Republic): Development of a Modular Enzyme Toolbox for the Synthesis of Tailored Multivalent Glycoconjugates
10:00 – 10:15 Vojtěch Hamala (Prague, Czech Republic): Tuning Galectin-1 Selectivity with Organometallic Glycocomplexes
10:15 – 10:30 Eva Paulenová (Brno, Czech Republic): Bacterial Lectins in Complex Bacterium-Nematode-Insect Tripartite System

Chair: Michaela Wimmerová

Katarína Mikušová (Bratislava, Slovakia): Uncovering the Secrets of Mycobacterial Cell Wall Assembly

Chairs: Michal Kolář, Martin Kolísek

13:30 – 14:00 Muhammad Khalid Muhammadi (Bratislava, Slovakia): Tau Pathology Causes Mitochondrial Dysfunction in a Rat model of Sporadic Alzheimer’s Disease
14:00 – 14:30 Martin Kolísek (Martin, Slovakia): Impact of a Complex Adjuvant Parkinson’s Disease Therapy on The Profile of Plasma Proteins
14:30 – 15:00 Michal Kolář (Prague, Czech Republic): The HOX Code of Human Adult Fibroblasts Reflects Their Developmental Origin

Chairs: Hana Lísalová, Jan Vacek

13:30 – 14:00 Zdeněk Farka (Brno, Czech Republic): Bioconjugates of Photon-Upconversion Nanoparticles as Background-Free Labels for Immunosensing and Imaging
14:00 – 14:30 Alžbeta Marček Chorvátová (Bratislava, Slovakia): Biosensing of the Interaction Between Photosynthetic Organisms and Silver Nanoparticles of Different Origins in the Aquatic Environment
14:30 – 14:40 Marek Petřivalský (Olomouc, Czech Republic): Roles and Targets of Protein S-Nitrosation in Signalling Pathways of Nitric Oxide During Plant Root Development and Stress Responses
14:40 – 14:50 Blanka Holendová (Prague, Czech Republic): Glucose-Stimulated Cysteine Redox Modifications Regulate Metabolic Adaptation in Pancreatic β-Cells
14:50 – 15:00 Hatef Bokaei (Brno, Czech Republic): Development and Characterization of a Gold Nanolayer Aptasensor for Interferon-Gamma

Chairs: Jan Vondráček, Albert Breier

13:30 – 14:00 Jan Vondráček (Brno, Czech Republic): Interactions of Polycyclic Aromatic Compounds with the Ah Receptor in the Context of Inflammation, Cellular Stress and Cell Phenotype
14:00 – 14:20 Sofía G. Zavala-Meneses (Prague, Czech Republic): Unraveling the Sulfamethoxazole Degradation Mechanisms of Kocuria rhizophila SA117: A Comprehensive Multiomic Study
14:20 – 14:40 Radka Václavíková (Prague, Czech Republic): Patient-derived Xenografts of Pancreatic Cancer for Study of Anticancer Drugs Efficacy and Development of Organoids Models
14:40 – 15:00 Albert Breier (Bratislava, Slovakia): Differential UVC Sensitivity in Multidrug-Resistant L1210 Cells: Role of p53 and Bcl-XL Expression and Function

Chair: Pavel Martásek

Erling Norrby (Stockholm, Sweden): Nobel Prizes and the Protein Folding Problem

Chair: Václav Martínek, Zuzana Staňáková

09:00 – 09:25 Pavlína Maloy Řezáčová (Prague, Czech Republic): Structural Biology Journey in Science and Drug Design
09:25 – 09:35 Zuzana Vávrová (Bratislava, Slovakia): Women in Life Sciences
09:35 – 09:55 Václav Martínek (Prague, Czech Republic): Enhancing Biochemistry Education through Biomolecular Visualization
09:55 – 10:05 Boris Lakatoš (Bratislava, Slovakia): What’s New in Teaching Biochemistry at the Faculty of Chemical and Food Technology STU
10:05 – 10:20 Jitka Richtová (České Budějovice, Czech Republic): Open Lab: Bridging Science, Schools, and Society through Hands-On Learning
10:20 – 10:30 Milan Kodíček (Prague, Czech Republic) et al.: Introduction of the New Textbook of Biochemistry

Chair: Vojtěch Spiwok

Artur Osyczka (Krakow, Poland): Molecular Operation of Cytochromes bc of Respiratory and Photosynthetic Electron Transport Chains

Chairs: Jiří Černý, Boris Klempa

12:15 – 12:45 Alena Panicucci Zíková (České Budějovice, Czech Republic): Reversal of ATP Synthase is a Key Attribute for Cellular Differentiation of Trypanosoma brucei Insect Forms
12:45 – 13:15 Michaela Rumlová (Prague, Czech Republic): The Way into the Nucleus and Back to the Cytosol: Critical Steps in the Retroviral Life Cycle
13:15 – 13:45 Divya Venkatesh (Oxford, United Kingdom): TBA

Chairs: Vojtěch Spiwok, Monika Švecová

12:15 – 12:45 David Hoksza (Prague, Czech Republic): Predicting Protein-Ligand Binding Sites – From a Static to a Dynamic View
12:45 – 13:15 Tomáš Pluskal (Prague, Czech Republic): TBA
13:15 – 13:30 Monika Švecová (Košice, Slovakia): Combined Urine and Serum Fluorescence Profiling using Machine Learning for Non-invasive Detection of Endometrial Cancer
13:30 – 13:45 Vojtěch Spiwok (Prague, Czech Republic): Amino Acids in the Context of Proteins

Chairs: Michael Wrzaczek, Viktor Demko

12:15 – 12:45 Viktor Demko (Bratislava, Slovakia): Searching for Targets of Plant’s Membrane-Anchored Calpain Protease DEK1
12:45 – 13:15 Michael Wrzaczek (České Budějovice, Czech Republic): The Receptor-like Kinase CRK2 Regulates Sugar Transport by Transporters and Plasmodesmata
13:15 – 13:45 Alexandra Hlavatá (Trnava, Slovakia): Phenotyping for Micronutrient Power: Advancing Zinc Biofortification in Wheat